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- Combine the existing filters into a consistent HTS system for identification
of poor leads
- Update each filter with your own expert knowledge by adding new
rules
- Catch new substructure-specific effects that cannot be described
by generic descriptors
- The cascade of four filters can screen >500 compounds per minute
- Add new filters based on analysis of your data
- Additional screens are under development - we are working on predicting
P-gP and CYP 450 affinities
- The following additional toxicity filters will be available shortly:
- Acute toxicity, LD50, intravenous administration in mice, N=18925;
- Acute toxicity, LD50, oral administration in mice: N=17150;
- Acute toxicity, LD50, subcutaneous administration in mice: N=7066;
- Acute toxicity, LD50, intraperitoneal administration in rats:
N=3471;
- Acute toxicity, LD50, oral administration in rats, N=5826.
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